10:15 - 11:15 am

Plenary: Deconstructing the Serotonin System in the Mouse Brain
Location: Grand Ballroom A-D

Serotonin powerfully modulate physiology and behavior in health and disease. In the mammalian brain, serotonin neurons are clustered in the raphe nuclei in the brainstem, but their axons innervate the entire brain. Our previous studies suggested that serotonin neurons likely comprise parallel subsystems with distinct transcriptomic features, projection patterns, input biases, physiological response properties, and behavioral functions (Ren et al., 2018; 2019). Building on these findings, I will describe three unpublished stories on (1) the architecture of serotonin projectome in the entire mouse brain; (2) deconstructing the serotonin system via the receptor axis; (3) modulation of female social behaviors by projection-specific serotonin neurons.